BACE inhibition-dependent repair of Alzheimer’s pathophysiology

Amyloid-β (Aβ) is thought to play an essential pathogenic role in Alzheimer´s disease (AD). A key enzyme involved in the generation of Aβ is the β-secretase BACE, for which powerful inhibitors have been developed and are currently in use in human clinical trials. However, although BACE inhibition ca...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Keskin, Aylin D., Kekuš, Maja, Adelsberger, Helmuth, Neumann, Ulf, Shimshek, Derya R., Song, Beomjong, Zott, Benedikt, Peng, Tingying, Förstl, Hans, Staufenbiel, Matthias, Nelken, Israel, Sakmann, Bert, Konnerth, Arthur, Busche, Marc Aurel
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559049/
https://ncbi.nlm.nih.gov/pubmed/28739891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708106114
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