Rho-associated kinase is a therapeutic target in neuroblastoma

Neuroblastoma is a peripheral neural system tumor that originates from the neural crest and is the most common and deadly tumor of infancy. Here we show that neuroblastoma harbors frequent mutations of genes controlling the Rac/Rho signaling cascade important for proper migration and differentiation...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Dyberg, Cecilia, Fransson, Susanne, Andonova, Teodora, Sveinbjörnsson, Baldur, Lännerholm-Palm, Jessika, Olsen, Thale K., Forsberg, David, Herlenius, Eric, Martinsson, Tommy, Brodin, Bertha, Kogner, Per, Johnsen, John Inge, Wickström, Malin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559038/
https://ncbi.nlm.nih.gov/pubmed/28739902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706011114
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