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Detection and quantification of inbreeding depression for complex traits from SNP data

Quantifying the effects of inbreeding is critical to characterizing the genetic architecture of complex traits. This study highlights through theory and simulations the strengths and shortcomings of three SNP-based inbreeding measures commonly used to estimate inbreeding depression (ID). We demonstr...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Yengo, Loic, Zhu, Zhihong, Wray, Naomi R., Weir, Bruce S., Yang, Jian, Robinson, Matthew R., Visscher, Peter M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558994/
https://ncbi.nlm.nih.gov/pubmed/28747529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621096114
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