Abundant and equipotent founder cells establish and maintain acute lymphoblastic leukaemia

High frequencies of blasts in primary acute lymphoblastic leukaemia (ALL) samples have the potential to induce leukaemia and to engraft mice. However, it is unclear how individual ALL cells each contribute to drive leukaemic development in a bulk transplant and the extent to which these blasts vary...

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Publicat a:Leukemia
Autors principals: Elder, A, Bomken, S, Wilson, I, Blair, H J, Cockell, S, Ponthan, F, Dormon, K, Pal, D, Heidenreich, O, Vormoor, J
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558874/
https://ncbi.nlm.nih.gov/pubmed/28487542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.140
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