Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice

BACKGROUND: Magnesium (Mg(2+)) is an essential cation implicated in carcinogenesis, solid tumor progression and metastatic potential. The Transient Receptor Potential Melastatin Member 7 (TRPM7) is a divalent ion channel involved in cellular and systemic Mg(2+) homeostasis. Abnormal expression of TR...

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Bibliographic Details
Published in:Cell Commun Signal
Main Authors: Huang, Junhao, Furuya, Hideki, Faouzi, Malika, Zhang, Zheng, Monteilh-Zoller, Mahealani, Kelly Galbraith Kawabata, F., Horgen, David, Kawamori, Toshihiko, Penner, Reinhold, Fleig, Andrea
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558780/
https://ncbi.nlm.nih.gov/pubmed/28810912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-017-0187-9
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