Phase I dose-escalation study of pazopanib combined with bevacizumab in patients with metastatic renal cell carcinoma or other advanced tumors

BACKGROUND: Vascular endothelial growth factor (VEGF) directed therapies are being used in a large number of advanced tumors. Metastatic renal cell carcinoma (mRCC) is highly dependent on the VEGF pathway; VEGF receptor (VEGFR) tyrosine kinase inhibitors (TKI) and humanized VEGF monoclonal antibody...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Négrier, Sylvie, Pérol, David, Bahleda, Rastislav, Hollebecque, Antoine, Chatelut, Etienne, Boyle, Helen, Cassier, Philippe, Metzger, Séverine, Blanc, Ellen, Soria, Jean-Charles, Escudier, Bernard
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558713/
https://ncbi.nlm.nih.gov/pubmed/28810837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3527-7
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