Discovery of bicyclic inhibitors against menaquinone biosynthesis

INTRODUCTION: Menaquinone is used for transporting electrons and is essential for the aerobic and anaerobic respiratory systems of all pathogens and prokaryotes. Many Gram-positive bacteria use only menaquinone in the electron transport system. Thus, menaquinone biosynthesis is a potential target fo...

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Detalles Bibliográficos
Publicado en:Future Med Chem
Main Authors: Choi, Seoung-ryoung, Larson, Marilynn A, Hinrichs, Steven H, Bartling, Amanda M, Frandsen, Joel, Narayanasamy, Prabagaran
Formato: Artigo
Idioma:Inglês
Publicado: Future Science Ltd 2016
Assuntos:
Preliminary Communication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558544/
https://ncbi.nlm.nih.gov/pubmed/26699277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc.15.168
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