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Cellular adaptation to xenobiotics: Interplay between xenosensors, reactive oxygen species and FOXO transcription factors

Cells adapt to an exposure to xenobiotics by upregulating the biosynthesis of proteins involved in xenobiotic metabolism. This is achieved largely via activation of cellular xenosensors that modulate gene expression. Biotransformation of xenobiotics frequently comes with the generation of reactive o...

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Dettagli Bibliografici
Pubblicato in:Redox Biol
Autori principali: Klotz, Lars-Oliver, Steinbrenner, Holger
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558470/
https://ncbi.nlm.nih.gov/pubmed/28818793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.07.015
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