Serum-derived extracellular vesicles (EVs) impact on vascular remodeling and prevent muscle damage in acute hind limb ischemia

Serum is an abundant and accessible source of circulating extracellular vesicles (EVs). Serum-EV (sEV) pro-angiogenic capability and mechanisms are herein analyzed using an in vitro assay which predicts sEV angiogenic potential in vivo. Effective sEVs (e-sEVs) also improved vascular remodeling and p...

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Udgivet i:Sci Rep
Main Authors: Cavallari, Claudia, Ranghino, Andrea, Tapparo, Marta, Cedrino, Massimo, Figliolini, Federico, Grange, Cristina, Giannachi, Valentina, Garneri, Paolo, Deregibus, Maria Chiara, Collino, Federica, Rispoli, Pietro, Camussi, Giovanni, Brizzi, Maria Felice
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557987/
https://ncbi.nlm.nih.gov/pubmed/28811546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08250-0
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