2,4,6-Trinitrotoluene Induces Apoptosis via ROS-Regulated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in HepG2 and Hep3B Cells

2,4,6-trinitrotoluene (TNT) has been reported to cause numerous adverse effects. However, the detailed molecular mechanisms underlying TNT-induced liver toxicity need to be elucidated. In this study, we used HepG2 (p53wt) and Hep3B (p53null) cell lines to investigate the cytotoxic effects of TNT. At...

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Publicado no:Sci Rep
Main Authors: Liao, Hung-Yu, Kao, Chih-Ming, Yao, Chao-Ling, Chiu, Po-Wei, Yao, Chun-Chen, Chen, Ssu-Ching
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557873/
https://ncbi.nlm.nih.gov/pubmed/28811603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08308-z
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