Quantification of mutant SPOP proteins in prostate cancer using mass spectrometry-based targeted proteomics

BACKGROUND: Speckle-type POZ protein (SPOP) is an E3 ubiquitin ligase adaptor protein that functions as a potential tumor suppressor, and SPOP mutations have been identified in ~10% of human prostate cancers. However, it remains unclear if mutant SPOP proteins can be utilized as biomarkers for early...

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Vydáno v:J Transl Med
Hlavní autoři: Wang, Hui, Barbieri, Christopher E., He, Jintang, Gao, Yuqian, Shi, Tujin, Wu, Chaochao, Schepmoes, Athena A., Fillmore, Thomas L., Chae, Sung-Suk, Huang, Dennis, Mosquera, Juan Miguel, Qian, Wei-Jun, Smith, Richard D., Srivastava, Sudhir, Kagan, Jacob, Camp, David G., Rodland, Karin D., Rubin, Mark A., Liu, Tao
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557563/
https://ncbi.nlm.nih.gov/pubmed/28810879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-017-1276-7
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