Expanding the Therapeutic Potential of the Iron Chelator Deferasirox in the Development of Aqueous Stable Ti(IV) Anticancer Complexes

The recent X-ray structure of titanium(IV)-bound human serum transferrin (STf) exhibiting citrate as a synergistic anion reveals a difference in Ti(IV) coordination versus iron(III), the metal endogenously delivered by the protein to cells. This finding enriches our bioinspired drug design strategy...

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Veröffentlicht in:Inorg Chem
Hauptverfasser: Loza-Rosas, Sergio A., Vázquez-Salgado, Alexandra M., Rivero, Kennett I., Negrón, Lenny J., Delgado, Yamixa, Benjamín-Rivera, Josué A., Vázquez-Maldonado, Angel L., Parks, Timothy B., Munet-Colón, Charlene, Tinoco, Arthur D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557045/
https://ncbi.nlm.nih.gov/pubmed/28644630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.inorgchem.7b00542
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