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Aging impairs alveolar macrophage phagocytosis and increases influenza-induced mortality in mice()

Influenza viral infections often lead to increased mortality in older people. However, the mechanisms by which aging impacts immunity to influenza lung infection remain unclear. We employed a murine model of influenza infection to identify these mechanisms. With aging, we found reduced numbers of al...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Wong, Christine K., Smith, Candice A., Sakamoto, Koji, Kaminski, Naftali, Koff, Jonathan L., Goldstein, Daniel R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5557035/
https://ncbi.nlm.nih.gov/pubmed/28646038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700397
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