In silico modeling identifies CD45 as a regulator of IL-2 synergy in the NKG2D-mediated activation of immature human NK cells

Natural killer (NK) cells perform immunosurveillance of virally infected and transformed cells, and their activation depends on the balance between signaling by inhibitory and activating receptors. Cytokine receptor signaling can synergize with activating receptor signaling to induce NK cell activat...

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Publicado en:Sci Signal
Autores principales: Mukherjee, Sayak, Jensen, Helle, Stewart, William, Stewart, David, Ray, William C., Chen, Shih-Yu, Nolan, Garry P., Lanier, Lewis L., Das, Jayajit
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5556952/
https://ncbi.nlm.nih.gov/pubmed/28655861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aai9062
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