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Cooperative binding mitigates the high-dose hook effect

BACKGROUND: The high-dose hook effect (also called prozone effect) refers to the observation that if a multivalent protein acts as a linker between two parts of a protein complex, then increasing the amount of linker protein in the mixture does not always increase the amount of fully formed complex....

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Dades bibliogràfiques
Publicat a:BMC Syst Biol
Autors principals: Roy, Ranjita Dutta, Rosenmund, Christian, Stefan, Melanie I.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5556679/
https://ncbi.nlm.nih.gov/pubmed/28807050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12918-017-0447-8
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