Cooperative effect of chidamide and chemotherapeutic drugs induce apoptosis by DNA damage accumulation and repair defects in acute myeloid leukemia stem and progenitor cells

BACKGROUND: Many conventional chemotherapeutic drugs are known to be involved in DNA damage, thus ultimately leading to apoptosis of leukemic cells. However, they fail to completely eliminate leukemia stem cells (LSCs) due to their higher DNA repair capacity of cancer stem cells than that of bulk ca...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Li, Yin, Wang, Yan, Zhou, Yong, Li, Jie, Chen, Kai, Zhang, Leisi, Deng, Manman, Deng, Suqi, Li, Peng, Xu, Bing
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5556349/
https://ncbi.nlm.nih.gov/pubmed/28814980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-017-0377-8
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