Role of glutamine and interlinked asparagine metabolism in vessel formation

Endothelial cell (EC) metabolism is emerging as a regulator of angiogenesis, but the precise role of glutamine metabolism in ECs is unknown. Here, we show that depriving ECs of glutamine or inhibiting glutaminase 1 (GLS1) caused vessel sprouting defects due to impaired proliferation and migration, a...

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Vydáno v:EMBO J
Hlavní autoři: Huang, Hongling, Vandekeere, Saar, Kalucka, Joanna, Bierhansl, Laura, Zecchin, Annalisa, Brüning, Ulrike, Visnagri, Asjad, Yuldasheva, Nadira, Goveia, Jermaine, Cruys, Bert, Brepoels, Katleen, Wyns, Sabine, Rayport, Stephen, Ghesquière, Bart, Vinckier, Stefan, Schoonjans, Luc, Cubbon, Richard, Dewerchin, Mieke, Eelen, Guy, Carmeliet, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5556263/
https://ncbi.nlm.nih.gov/pubmed/28659375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695518
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