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Screening drug-target interactions with positive-unlabeled learning

Identifying drug-target interaction (DTI) candidates is crucial for drug repositioning. However, usually only positive DTIs are deposited in known databases, which challenges computational methods to predict novel DTIs due to the lack of negative samples. To overcome this dilemma, researchers usuall...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Peng, Lihong, Zhu, Wen, Liao, Bo, Duan, Yu, Chen, Min, Chen, Yi, Yang, Jialiang
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2017
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5556112/
https://ncbi.nlm.nih.gov/pubmed/28808275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08079-7
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