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– (-) Menthol Induces Reversal of Promoter Hypermethylation and Associated Up-Regulation of the FANCF Gene in the SiHa Cell Line

OBJECTIVE: To identify natural bioactive molecules with potential to inhibit DNA methyltransferase 1 (DNMT1) and cause reactivation of genes silenced due to promoter hypermethylation. METHODS AND RESULTS: -(-) Menthol and epigallocatechin-3-gallate (EGCG) (reference molecule) were investigated using...

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Detalhes bibliográficos
Publicado no:Asian Pac J Cancer Prev
Main Authors: Parashar, Gaurav, Parashar, Nidarshana Chaturvedi, Capalash, Neena
Formato: Artigo
Idioma:Inglês
Publicado em: West Asia Organization for Cancer Prevention 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555548/
https://ncbi.nlm.nih.gov/pubmed/28612587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22034/APJCP.2017.18.5.1365
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