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Disease-linked mutations in factor H reveal pivotal role of cofactor activity in self-surface–selective regulation of complement activation
Spontaneous activation enables the complement system to respond very rapidly to diverse threats. This activation is efficiently suppressed by complement factor H (CFH) on self-surfaces but not on foreign surfaces. The surface selectivity of CFH, a soluble protein containing 20 complement-control pro...
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| Vydáno v: | J Biol Chem |
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| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Biochemistry and Molecular Biology
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5555194/ https://ncbi.nlm.nih.gov/pubmed/28637873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.795088 |
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