Dual RNA Processing Roles of Pat1b via Cytoplasmic Lsm1-7 and Nuclear Lsm2-8 Complexes

Pat1 RNA-binding proteins, enriched in processing bodies (P bodies), are key players in cytoplasmic 5′ to 3′ mRNA decay, activating decapping of mRNA in complex with the Lsm1-7 heptamer. Using co-immunoprecipitation and immunofluorescence approaches coupled with RNAi, we provide evidence for a nucle...

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Pubblicato in:Cell Rep
Autori principali: Vindry, Caroline, Marnef, Aline, Broomhead, Helen, Twyffels, Laure, Ozgur, Sevim, Stoecklin, Georg, Llorian, Miriam, Smith, Christopher W., Mata, Juan, Weil, Dominique, Standart, Nancy
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554784/
https://ncbi.nlm.nih.gov/pubmed/28768202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.06.091
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