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Heme trafficking and modifications during system I cytochrome c biogenesis: insights from heme redox potentials of Ccm proteins

Cytochromes c require covalent attachment of heme via two thioether bonds at conserved CXXCH motifs, a process accomplished in prokaryotes by eight integral membrane proteins (CcmABCDEFGH), termed System I. Heme is trafficked from inside the cell to outside (via CcmABCD) and chaperoned (holoCcmE) to...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Sutherland, Molly C., Rankin, Joel A., Kranz, Robert G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554621/
https://ncbi.nlm.nih.gov/pubmed/27198710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00427
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