The evolution of methicillin resistance in Staphylococcus aureus: Similarity of genetic backgrounds in historically early methicillin-susceptible and -resistant isolates and contemporary epidemic clones

The key genetic component of methicillin resistance, the mecA determinant, is not native to Staphylococcus aureus. Thus, the evolution of methicillin-resistant S. aureus (MRSA) must have begun with the acquisition of the mecA determinant from an unknown heterologous source some time before the first...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Crisóstomo, M. Inês, Westh, Henrik, Tomasz, Alexander, Chung, Marilyn, Oliveira, Duarte C., de Lencastre, Hermínia
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2001
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55544/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11481426/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.161272898
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