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Mechanism of the mRNA guanylyltransferase reaction: isolation of N epsilon-phospholysine and GMP (5' leads to N epsilon) lysine from the guanylyl-enzyme intermediate.

The mRNA capping reaction catalyzed by rat liver mRNA guanylyltransferase proceeds through an enzyme-GMP intermediate in which GMP is linked to the enzyme by a phosphoamide linkage. The studies described here show that GMP is bound to the epsilon-amino group of lysine of rat liver guanylyltransferas...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Toyama, R, Mizumoto, K, Nakahara, Y, Tatsuno, T, Kaziro, Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1983
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC555434/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6321153/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1983.tb01723.x
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