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Synergistic protection against acute flurothyl–induced seizures by adjuvant treatment of the ketogenic diet with the Type II Diabetes drug pioglitazone
OBJECTIVE: We have previously found that the transcription factor PPARγ contributes to the mechanism of action of the ketogenic diet (KD), an established treatment for pediatric refractory epilepsy. We have found that the KD increases brain PPARγ and that inhibition or genetic loss of PPARγ prevents...
Gardado en:
| Publicado en: | Epilepsia |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5554083/ https://ncbi.nlm.nih.gov/pubmed/28555877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.13809 |
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