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LSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer
BACKGROUND: Lysine-specific demethylase 1A (LSD1) is a key regulator of the androgen (AR) and estrogen receptors (ER), and LSD1 levels correlate with tumor aggressiveness. Here, we demonstrate that LSD1 regulates vitamin D receptor (VDR) activity and is a mediator of 1,25(OH)(2)-D(3) (vitamin D) act...
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| Publicado no: | Clin Epigenetics |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5553900/ https://ncbi.nlm.nih.gov/pubmed/28811844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-017-0382-y |
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