LSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer

BACKGROUND: Lysine-specific demethylase 1A (LSD1) is a key regulator of the androgen (AR) and estrogen receptors (ER), and LSD1 levels correlate with tumor aggressiveness. Here, we demonstrate that LSD1 regulates vitamin D receptor (VDR) activity and is a mediator of 1,25(OH)(2)-D(3) (vitamin D) act...

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Bibliographic Details
Published in:Clin Epigenetics
Main Authors: Battaglia, Sebastiano, Karasik, Ellen, Gillard, Bryan, Williams, Jennifer, Winchester, Trisha, Moser, Michael T., Smiraglia, Dominic J, Foster, Barbara A.
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553900/
https://ncbi.nlm.nih.gov/pubmed/28811844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-017-0382-y
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