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Sirt3 attenuates doxorubicin-induced cardiac hypertrophy and mitochondrial dysfunction via suppression of Bnip3

Doxorubicin (Dox) is an anthracycline antibiotic widely used in cancer treatment. Although its antitumor efficacy appears to be dose dependent, its clinical use is greatly restricted by development of cardiotoxicity. Sirtuin-3 (Sirt3) is the major deacetylase within the mitochondrial matrix that pla...

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Bibliografske podrobnosti
izdano v:Am J Transl Res
Main Authors: Du, Qiong, Zhu, Bin, Zhai, Qing, Yu, Bo
Format: Artigo
Jezik:Inglês
Izdano: e-Century Publishing Corporation 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553885/
https://ncbi.nlm.nih.gov/pubmed/28804553
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