Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases

MPTP-mouse model constitutes a well-known model of neuroinflammation and mitochondrial failure occurring in Parkinson’s disease (PD). Although it has been extensively reported that nitric oxide (NO(●)) plays a key role in the pathogenesis of PD, the relative roles of nitric oxide synthase isoforms i...

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Publicado en:PLoS One
Main Authors: López, Ana, Ortiz, Francisco, Doerrier, Carolina, Venegas, Carmen, Fernández-Ortiz, Marisol, Aranda, Paula, Díaz-Casado, María E., Fernández-Gil, Beatriz, Barriocanal-Casado, Eliana, Escames, Germaine, López, Luis C., Acuña-Castroviejo, Darío
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553810/
https://ncbi.nlm.nih.gov/pubmed/28800639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0183090
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