A CLCA regulatory protein present in the chemosensory cilia of olfactory sensory neurons induces a Ca(2+)-activated Cl(−) current when transfected into HEK293

BACKGROUND: CLCA is a family of metalloproteases that regulate Ca(2+)-activated Cl(−) fluxes in epithelial tissues. In HEK293 cells, CLCA1 promotes membrane expression of an endogenous Anoctamin 1 (ANO1, also termed TMEM16A)-dependent Ca(2+)-activated Cl(−) current. Motif architecture similarity wit...

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Detalhes bibliográficos
Publicado no:BMC Neurosci
Main Authors: Mura, Casilda V., Delgado, Ricardo, Delgado, María Graciela, Restrepo, Diego, Bacigalupo, Juan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553735/
https://ncbi.nlm.nih.gov/pubmed/28800723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12868-017-0379-7
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