Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly

Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is derived from a single dominant hematopoietic stem cell lineage. Somatic mutations in candidate driver (CD) genes are thought to be responsible for at least some cases of CH. Using whole-genome sequencing of 11 26...

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書誌詳細
出版年:Blood
主要な著者: Zink, Florian, Stacey, Simon N., Norddahl, Gudmundur L., Frigge, Michael L., Magnusson, Olafur T., Jonsdottir, Ingileif, Thorgeirsson, Thorgeir E., Sigurdsson, Asgeir, Gudjonsson, Sigurjon A., Gudmundsson, Julius, Jonasson, Jon G., Tryggvadottir, Laufey, Jonsson, Thorvaldur, Helgason, Agnar, Gylfason, Arnaldur, Sulem, Patrick, Rafnar, Thorunn, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F., Masson, Gisli, Kong, Augustine, Stefansson, Kari
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2017
主題:
Hematopoiesis and Stem Cells
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553576/
https://ncbi.nlm.nih.gov/pubmed/28483762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-02-769869
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