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Structural Analysis of Heparin-Derived 3-O-Sulfated Tetrasaccharides: Antithrombin Binding Site Variants

Heparin is a polysaccharide that is widely used as an anticoagulant drug. The mechanism for heparin’s anticoagulant activity is primarily through its interaction with a serine protease inhibitor, antithrombin III (AT), that enhances its ability to inactivate blood coagulation serine proteases, inclu...

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Dades bibliogràfiques
Publicat a:J Pharm Sci
Autors principals: Chen, Yin, Lin, Lei, Agyekum, Isaac, Zhang, Xing, St Ange, Kalib, Yu, Yanlei, Zhang, Fuming, Liu, Jian, Amster, I. Jonathan, Linhardt, Robert J.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553205/
https://ncbi.nlm.nih.gov/pubmed/28007564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2016.11.023
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