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Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2

Juvenile nephronophthisis type 1 is caused by mutations of NPHP1, the gene encoding for nephrocystin. The function of nephrocystin is presently unknown, but the presence of a Src homology 3 domain and its recently described interaction with p130(Cas) suggest that nephrocystin is part of the focal ad...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Benzing, Thomas, Gerke, Peter, Höpker, Katja, Hildebrandt, Friedhelm, Kim, Emily, Walz, Gerd
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55530/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11493697/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.171269898
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