The VEGF-A inhibitor sFLT-1 improves renal function by reducing endothelial activation and inflammation in a mouse model of type 1 diabetes

AIMS/HYPOTHESIS: Animal models of diabetic nephropathy show increased levels of glomerular vascular endothelial growth factor (VEGF)-A, and several studies have shown that inhibiting VEGF-A in animal models of diabetes can prevent albuminuria and glomerular hypertrophy. However, in those studies, tr...

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Bibliographic Details
Published in:Diabetologia
Main Authors: Bus, Pascal, Scharpfenecker, Marion, Van Der Wilk, Priscilla, Wolterbeek, Ron, Bruijn, Jan A., Baelde, Hans J.
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552850/
https://ncbi.nlm.nih.gov/pubmed/28620823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-017-4322-3
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