SNAP-25b-deficiency increases insulin secretion and changes spatiotemporal profile of Ca(2+)oscillations in β cell networks

SNAP-25 is a protein of the core SNARE complex mediating stimulus-dependent release of insulin from pancreatic β cells. The protein exists as two alternatively spliced isoforms, SNAP-25a and SNAP-25b, differing in 9 out of 206 amino acids, yet their specific roles in pancreatic β cells remain unclea...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Daraio, Teresa, Bombek, Lidija Križančić, Gosak, Marko, Valladolid-Acebes, Ismael, Klemen, Maša Skelin, Refai, Essam, Berggren, Per-Olof, Brismar, Kerstin, Rupnik, Marjan Slak, Bark, Christina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552776/
https://ncbi.nlm.nih.gov/pubmed/28798351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08082-y
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