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SNAP-25b-deficiency increases insulin secretion and changes spatiotemporal profile of Ca(2+)oscillations in β cell networks
SNAP-25 is a protein of the core SNARE complex mediating stimulus-dependent release of insulin from pancreatic β cells. The protein exists as two alternatively spliced isoforms, SNAP-25a and SNAP-25b, differing in 9 out of 206 amino acids, yet their specific roles in pancreatic β cells remain unclea...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5552776/ https://ncbi.nlm.nih.gov/pubmed/28798351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08082-y |
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