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Novel Therapeutic Approach to Improve Hematopoiesis in low risk MDS by Targeting MDSCs with The Fc-engineered CD33 Antibody BI 836858
We recently reported that the accumulation of myeloid-derived suppressor cells (MDSC), defined as CD33(+)HLA-DR(−)Lin(−), plays a direct role in the pathogenesis of myelodysplastic syndrome (MDS). In particular, CD33 is strongly expressed in MDSC isolated from patients with MDS where it plays an imp...
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Wydane w: | Leukemia |
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Główni autorzy: | , , , , , , , , , , , , , |
Format: | Artigo |
Język: | Inglês |
Wydane: |
2017
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Hasła przedmiotowe: | |
Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5552472/ https://ncbi.nlm.nih.gov/pubmed/28096534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.21 |
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