Novel Therapeutic Approach to Improve Hematopoiesis in low risk MDS by Targeting MDSCs with The Fc-engineered CD33 Antibody BI 836858

We recently reported that the accumulation of myeloid-derived suppressor cells (MDSC), defined as CD33(+)HLA-DR(−)Lin(−), plays a direct role in the pathogenesis of myelodysplastic syndrome (MDS). In particular, CD33 is strongly expressed in MDSC isolated from patients with MDS where it plays an imp...

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Pubblicato in:Leukemia
Autori principali: Eksioglu, Erika A., Chen, Xianghong, Heider, Karl-Heinz, Rueter, Bjoern, McGraw, Kathy L., Basiorka, Ashley A., Wei, Max, Burnette, Alexis, Cheng, Pinyang, Lancet, Jeffrey, Komrokji, Rami, Djeu, Julie, List, Alan, Wei, Sheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552472/
https://ncbi.nlm.nih.gov/pubmed/28096534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.21
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