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Epigenetic differences between monozygotic twins discordant for amyotrophic lateral sclerosis (ALS) provide clues to disease pathogenesis

Amyotrophic lateral sclerosis (ALS) is a devastating late-onset neurodegenerative disorder in which only a small proportion of patients carry an identifiable causative genetic lesion. Despite high heritability estimates, a genetic etiology for most sporadic ALS remains elusive. Here we report the ep...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Young, Paul E., Kum Jew, Stephen, Buckland, Michael E., Pamphlett, Roger, Suter, Catherine M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552194/
https://ncbi.nlm.nih.gov/pubmed/28797086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182638
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