Modeling the human Na(v)1.5 sodium channel: structural and mechanistic insights of ion permeation and drug blockade

Abnormalities in the human Na(v)1.5 (hNa(v)1.5) voltage-gated sodium ion channel (VGSC) are associated with a wide range of cardiac problems and diseases in humans. Current structural models of hNa(v)1.5 are still far from complete and, consequently, their ability to study atomistic interactions of...

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Detaylı Bibliyografya
Yayımlandı:Drug Des Devel Ther
Asıl Yazarlar: Ahmed, Marawan, Jalily Hasani, Horia, Ganesan, Aravindhan, Houghton, Michael, Barakat, Khaled
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Dove Medical Press 2017
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552146/
https://ncbi.nlm.nih.gov/pubmed/28831242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S133944
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