Dose and timing of injections for effective cyclosporine A pretreatment before renal ischemia reperfusion in mice

BACKGROUND: There is experimental evidence that lethal ischemia-reperfusion injury (IRI) is largely due to mitochondrial permeability transition pore (mPTP) opening, which can be prevented by cyclosporine A (CsA). The aim of our study is to show that a higher dose of CsA (10 mg/kg) injected just bef...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lemoine, Sandrine, Pillot, Bruno, Augeul, Lionel, Rabeyrin, Maud, Varennes, Annie, Normand, Gabrielle, Baetz, Delphine, Ovize, Michel, Juillard, Laurent
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552114/
https://ncbi.nlm.nih.gov/pubmed/28796779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182358
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