SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway

Loss of chromosome 18q21 is well documented in colorectal cancer, and it has been suggested that this loss targets the DCC, DPC4/SMAD4, and SMAD2 genes. Recently, the importance of SMAD4, a downstream regulator in the TGF-β signaling pathway, in colorectal cancer has been highlighted, although the f...

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Detalles Bibliográficos
Main Authors: Woodford-Richens, K. L., Rowan, A. J., Gorman, P., Halford, S., Bicknell, D. C., Wasan, H. S., Roylance, R. R., Bodmer, W. F., Tomlinson, I. P. M.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC55519/
https://ncbi.nlm.nih.gov/pubmed/11481457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.171321498
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