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The promise of CaMKII inhibition for heart disease: preventing heart failure and arrhythmias

INTRODUCTION: Calcium-calmodulin-dependent protein kinase II (CaMKII) has emerged as a central mediator of cardiac stress responses which may serve several critical roles in the regulation of cardiac rhythm, cardiac contractility and growth. Sustained and excessive activation of CaMKII during cardia...

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Publicat a:Expert Opin Ther Targets
Autors principals: Westenbrink, B Daan, Edwards, Andrew G, McCulloch, Andrew D, Brown, Joan Heller
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551677/
https://ncbi.nlm.nih.gov/pubmed/23789646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/14728222.2013.809064
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