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Instant Hydrogelation Inspired by Inflammasomes
Based on the recent near-atomic structures of the PYRIN domain of ASC in the protein filament of inflammasomes and the observation of the active form of vitamin B6 (pyridoxal phosphate, P5P) modulates the self-assembly of ASC, we rationally designed an N-terminal capped nonapeptide (Nap-FFKKFKLKL, 1...
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| Publicado no: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5551645/ https://ncbi.nlm.nih.gov/pubmed/28481474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201702783 |
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