Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies

Vaccines remain the most effective tool to prevent infectious diseases. Here, we introduce an in vitro booster vaccination approach that relies on antigen-dependent activation of human memory B cells in culture. This stimulation induces antigen-specific B cell proliferation, differentiation of B cel...

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Vydáno v:J Exp Med
Hlavní autoři: Sanjuan Nandin, Irene, Fong, Carol, Deantonio, Cecilia, Torreno-Pina, Juan A., Pecetta, Simone, Maldonado, Paula, Gasparrini, Francesca, Ordovas-Montanes, Jose, Kazer, Samuel W., Kjaer, Svend, Borley, Daryl W., Nair, Usha, Coleman, Julia A., Lingwood, Daniel, Shalek, Alex K., Meffre, Eric, Poignard, Pascal, Burton, Dennis R., Batista, Facundo D.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2017
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551578/
https://ncbi.nlm.nih.gov/pubmed/28739603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170633
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