Therapeutic antibody targeting of Notch3 signaling prevents mural cell loss in CADASIL

Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a neurological syndrome characterized by small vessel disease (SVD), stroke, and vascular cognitive impairment and dementia caused by mutations in NOTCH3. No therapies are available for this condi...

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Dettagli Bibliografici
Pubblicato in:J Exp Med
Autori principali: Machuca-Parra, Arturo I., Bigger-Allen, Alexander A., Sanchez, Angie V., Boutabla, Anissa, Cardona-Vélez, Jonathan, Amarnani, Dhanesh, Saint-Geniez, Magali, Siebel, Christian W., Kim, Leo A., D’Amore, Patricia A., Arboleda-Velasquez, Joseph F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2017
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551569/
https://ncbi.nlm.nih.gov/pubmed/28698285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161715
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