NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity

Mitochondrial dysfunction is the most prominent source of oxidative stress in acute and chronic kidney disease. NLRX1 is a receptor of the innate immune system that is ubiquitously expressed and localized in mitochondria. We investigated whether NLRX1 may act at the interface of metabolism and innat...

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Publicat a:J Exp Med
Autors principals: Stokman, Geurt, Kors, Lotte, Bakker, Pieter J., Rampanelli, Elena, Claessen, Nike, Teske, Gwendoline J.D., Butter, Loes, van Andel, Harmen, van den Bergh Weerman, Marius A., Larsen, Per W.B., Dessing, Mark C., Zuurbier, Coert J., Girardin, Stephen E., Florquin, Sandrine, Leemans, Jaklien C.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2017
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551566/
https://ncbi.nlm.nih.gov/pubmed/28626071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161031
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