iRGD-functionalized PEGylated nanoparticles for enhanced colon tumor accumulation and targeted drug delivery

AIM: To enhance the tumor accumulation and targeted drug delivery for colon cancer therapy, iRGD peptide was introduced to the surface of PEGylated camptothecin-loaded nanoparticles (NPs). METHODS: Cellular uptake, targeting specificity, biodistribution and antitumor capacity were evaluated. RESULTS...

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Pubblicato in:Nanomedicine (Lond)
Autori principali: Ma, Lijun, Chen, Qiubing, Ma, Panpan, Han, Moon Kwon, Xu, Zhigang, Kang, Yuejun, Xiao, Bo, Merlin, Didier
Natura: Artigo
Lingua:Inglês
Pubblicazione: Future Medicine Ltd 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551526/
https://ncbi.nlm.nih.gov/pubmed/28745123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/nnm-2017-0107
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