High affinity binding of alpha-bungarotoxin to the purified alpha-subunit and to its 27,000-dalton proteolytic peptide from Torpedo marmorata acetylcholine receptor. Requirement for sodium dodecyl sulfate.

Intact nicotinic acetylcholine receptor (AChR) tightly binds alpha-bungarotoxin. The two toxin-binding sites are presumed to be on the two alpha-subunits, either on or near the ACh-binding sites. Isolated alpha-subunits have been found to maintain weak binding to alpha-bungarotoxin (KD approximately...

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Bibliographische Detailangaben
Veröffentlicht in:EMBO J
Hauptverfasser: Tzartos, S J, Changeux, J P
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1983
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC555144/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11894953/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1983.tb01434.x
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