Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel candidate genes for pulmonary function

BACKGROUND: Failure to attain peak lung function by early adulthood is a risk factor for chronic lung diseases. Previously, we reported that C3H/HeJ mice have about twice total lung capacity (TLC) compared to JF1/MsJ mice. We identified seven lung function quantitative trait loci (QTL: Lfnq1-Lfnq7)...

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Bibliografiske detaljer
Udgivet i:Respir Res
Main Authors: George, Leema, Mitra, Ankita, Thimraj, Tania A., Irmler, Martin, Vishweswaraiah, Sangeetha, Lunding, Lars, Hühn, Dorothea, Madurga, Alicia, Beckers, Johannes, Fehrenbach, Heinz, Upadhyay, Swapna, Schulz, Holger, Leikauf, George D., Ganguly, Koustav
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551015/
https://ncbi.nlm.nih.gov/pubmed/28793908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-017-0629-3
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