Hydroxychloroquine inhibits CD154 expression in CD4(+) T lymphocytes of systemic lupus erythematosus through NFAT, but not STAT5, signaling

BACKGROUND: Overexpression of membranous CD154 in T lymphocytes has been found previously in systemic lupus erythematosus (SLE). Because hydroxychloroquine (HCQ) has been used frequently in the treatment of lupus, we sought to identify the effects of HCQ on CD154 and a possibly regulatory mechanism....

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Wu, Shu-Fen, Chang, Chia-Bin, Hsu, Jui-Mei, Lu, Ming-Chi, Lai, Ning-Sheng, Li, Chin, Tung, Chien-Hsueh
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550984/
https://ncbi.nlm.nih.gov/pubmed/28793932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-017-1393-y
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