Antagomirs Targeting MiroRNA-134 Attenuates Epilepsy in Rats through Regulation of Oxidative Stress, Mitochondrial Functions and Autophagy

The effects of the existing anti-epileptic drugs are unsatisfactory to almost one third of epileptic patients. MiR-134 antagomirs prevent pilocarpine-induced status epilepticus. In this study, a lithium chloride-pilocarpine-induced status epilepticus model was established and treated with intracereb...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Sun, Jiahang, Gao, Xiaoying, Meng, Dawei, Xu, Yang, Wang, Xichun, Gu, Xin, Guo, Mian, Shao, Xiaodong, Yan, Hongwen, Jiang, Chuanlu, Zheng, Yongri
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550691/
https://ncbi.nlm.nih.gov/pubmed/28848439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00524
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